What precaution is recommended when taking prednisone due to GI irritation?

• A. Take with water only
• B. Take with milk or food
• C. Take on an empty stomach
• D. Take at bedtime only

Answer: (B)

Prednisone can irritate the stomach lining, so the precaution is to take it with food or milk to buffer and protect the gastric mucosa. Food or dairy slows and buffers the contact of the medication with the stomach lining, reducing the risk of gastritis, ulcers, or significant GI upset. Taking it with water alone wouldn’t provide this buffering effect, and taking it on an empty stomach can worsen irritation. Taking the dose at bedtime doesn’t address the GI-protective need and isn’t recommended as the sole precaution. If GI symptoms persist, consult the clinician, which may lead to adjustments in dosing or additional protective strategies.