Naloxone is indicated for reversal of which condition?

• A. Treats bacterial infections.
• B. Reversal of opioid depression and respiratory depression.
• C. Relieves severe pain.
• D. Lowers blood pressure.

Answer: (B)

Naloxone is used to reverse opioid-induced depression of the central nervous system and respiratory drive. It works by acting as a competitive antagonist at mu receptors, displacing opioids from their receptors and rapidly restoring breathing and consciousness after an opioid overdose. Because some opioids last longer than naloxone, repeated dosing or a short-term infusion may be needed to prevent recurrence of respiratory depression. It’s important to monitor for withdrawal symptoms in people who are opioid-dependent and to be prepared for possible re-sedation if the opioid effect returns. This medication is specific to opioids and will not treat bacterial infections, is not an analgesic (and can precipitate withdrawal or worsen pain control by removing opioid analgesia), and is not used to lower blood pressure.